2. Academic Validation
  3. Labdane-type diterpenoids from the fruits of Vitex trifolia

Labdane-type diterpenoids from the fruits of Vitex trifolia

  • J Nat Prod. 2013 Feb 22;76(2):287-91. doi: 10.1021/np300679x.
Cheng-Jian Zheng 1,  Jian-Yong Zhu,  Wu Yu,  Xue-Qin Ma,  Khalid Rahman,  Lu-Ping Qin
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 23327905 DOI: 10.1021/np300679x
Abstract

Seven new labdane-type Diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human Cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg/mL).

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