Alkaloids from Sri Lankan curry-leaf (Murraya koenigii) display melanogenesis inhibitory activity: structures of karapinchamines A and B

Bioorg Med Chem. 2013 Mar 1;21(5):1043-9. doi: 10.1016/j.bmc.2013.01.012.

Seikou Nakamura ¹, Souichi Nakashima, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Tomoe Ohta, Keiko Ogawa, Sayuri Maeda, Shino Nishida, Hisashi Matsuda, Masayuki Yoshikawa

Affiliations

Affiliation

1 Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Japan.

PMID: 23376010 DOI: 10.1016/j.bmc.2013.01.012

Abstract

A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new Carbazole Alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble fraction together with 12 known Carbazole Alkaloids. The structures of karapinchamines A and B were determined by physicochemical analyses. The principal alkaloid constituents were found to display potent melanogenesis inhibitory activity. The structural requirements of the Carbazole Alkaloids for melanogenesis inhibitory activity were discussed.

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