2. Academic Validation
  3. Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa

Melanogenesis inhibitory daphnane diterpenoids from the flower buds of Daphne genkwa

  • Bioorg Med Chem Lett. 2013 Jun 1;23(11):3334-7. doi: 10.1016/j.bmcl.2013.03.096.
Kwon Ki Bang 1,  Cheong-Yong Yun,  Chul Lee,  Qinghao Jin,  Jin Woo Lee,  Sang-Hun Jung,  Dongho Lee,  Mi Kyeong Lee,  Jin Tae Hong,  Youngsoo Kim,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
PMID: 23623417 DOI: 10.1016/j.bmcl.2013.03.096
Abstract

Two new daphnane-type diterpene esters, daphneresiniferins A (1) and B (2), along with seven known diterpenes, yuanhuacine (3), yuanhuadine (4), yuanhuahine (5), genkwadaphnin (6), genkwanine A (7), genkwanine F (8), and genkwanine H (9), were isolated from the methanol extract of the flower buds of Daphne genkwa. Their structures were elucidated on the basis of spectroscopic methods, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All the isolates were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.

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