2. Academic Validation
  3. Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors

  • Bioorg Med Chem Lett. 2013 Jun 1;23(11):3385-8. doi: 10.1016/j.bmcl.2013.03.077.
Longhu Zhou 1,  Franck Amblard,  Hongwang Zhang,  Tamara R McBrayer,  Mervi A Detorio,  Tony Whitaker,  Steven J Coats,  Raymond F Schinazi
Affiliations

Affiliation

  • 1 Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Decatur, GA 30033, USA.
PMID: 23623492 DOI: 10.1016/j.bmcl.2013.03.077
Abstract

The synthesis of new ribo and 2'-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells.

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