2. Academic Validation
  3. Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

  • Bioorg Med Chem Lett. 2013 Jul 15;23(14):4263-6. doi: 10.1016/j.bmcl.2013.04.032.
Chul Lee 1,  Jin Woo Lee,  Qinghao Jin,  Dae Sik Jang,  Sung-Joon Lee,  Dongho Lee,  Jin Tae Hong,  Youngsoo Kim,  Mi Kyeong Lee,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
PMID: 23743282 DOI: 10.1016/j.bmcl.2013.04.032
Abstract

Two new Isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as (1)D, (2)D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC50 value of 18.1μM.

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