Antiplasmodial and cytotoxic flavans and diarylpropanes from the stems of Combretum griffithii

Four new flavans, griffinoids A-D (1-4), and two new diarylpropanes, griffithanes E and F (7 and 8), together with two known flavans (5 and 6), four known diarylpropanes, and β-sitosterol, were isolated from the EtOAc extract of the stems of Combretum griffithii. Compounds 3, 4, 5, and 9 exhibited weak antiplasmodial activity, with IC50 values of 15.74, 13.04, 9.66, and 14.45 μM, respectively. In addition, compounds 4, 5, and 8 also exhibited weak cytotoxicity toward one or more Cancer cell lines including human epidermoid carcinoma, human breast Cancer, and human small cell lung Cancer cell lines.