2. Academic Validation
  3. Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil)

Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil)

  • J Nat Prod. 2013 Jul 26;76(7):1376-9. doi: 10.1021/np400326e.
Ki Hyun Kim 1,  Sang Un Choi,  Mi Won Son,  Sang Zin Choi,  Jon Clardy,  Kang Ro Lee
Affiliations

Affiliation

  • 1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.
PMID: 23815260 DOI: 10.1021/np400326e
Abstract

Pharbinilic acid (1), the first naturally occurring allogibberic acid, was isolated from ethanol extracts of morning glory (Pharbitis nil) seeds. Its absolute configuration was determined by NOESY NMR and ECD experiments. Compound 1 showed weak cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cells and weakly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglia cells.

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