2. Academic Validation
  3. Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii

  • J Nat Prod. 2013 Jul 26;76(7):1388-91. doi: 10.1021/np400404r.
Karen Co Tan 1,  Toshiyuki Wakimoto,  Kentaro Takada,  Takashi Ohtsuki,  Nahoko Uchiyama,  Yukihiro Goda,  Ikuro Abe
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033, Japan.
PMID: 23848233 DOI: 10.1021/np400404r
Abstract

A macrocylic dodecapeptide, cycloforskamide, was isolated from the sea slug Pleurobranchus forskalii, collected off Ishigaki Island, Japan. Its planar structure was deduced by extensive NMR analyses and was further confirmed by MS/MS fragmentation analyses. Finally, the absolute configuration was determined by total hydrolysis and chiral-phase gas chromatographic analysis. This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC50 of 5.8 μM.

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