2. Academic Validation
  3. Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents

Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents

  • Bioorg Med Chem Lett. 2013 Sep 1;23(17):5002-5. doi: 10.1016/j.bmcl.2013.06.040.
Liqiang Wu 1,  Chong Zhang,  Weilin Li
Affiliations

Affiliation

  • 1 School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. wliq1974@163.com
PMID: 23871222 DOI: 10.1016/j.bmcl.2013.06.040
Abstract

Three-component coupling of aldehyde, 2-hydroxy-1,4-naphthoquinone and 3-amino-1,2,4-triazole has been achieved using a catalytic amount of sulfamic acid under solvent free conditions to produce a novel series of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-dione derivatives in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.

Keywords

2-Hydroxy-1,4-naphthoquinone; Aldehydes; Antitumor; Ortho-Naphthoquinone; Solvent-free; Sulfamic acid.

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