1. Academic Validation
  2. Antiviral activity of angelicin against gammaherpesviruses

Antiviral activity of angelicin against gammaherpesviruses

  • Antiviral Res. 2013 Oct;100(1):75-83. doi: 10.1016/j.antiviral.2013.07.009.
Hye-Jeong Cho 1 Seon-Gyeong Jeong Ji-Eun Park Jin-Ah Han Hye-Ri Kang Dongho Lee Moon Jung Song
Affiliations

Affiliation

  • 1 Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.
Abstract

Human gammaherpesviruses including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are important pathogens as they persist in the host and cause various malignancies. However, few Antiviral drugs are available to efficiently control gammaherpesvirus replication. Here we identified the Antiviral activity of angelicin against murine gammaherpesvirus 68 (MHV-68), genetically and biologically related to human gammaherpesviruses. Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, efficiently inhibited lytic replication of MHV-68 in a dose-dependent manner following the virus entry. The IC50 of angelicin Antiviral activity was estimated to be 28.95μM, while the CC50 of angelicin was higher than 2600μM. Furthermore, incubation with angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Taken together, these results suggest that MHV-68 can be a useful tool to screen novel Antiviral agents against human gammaherepsviruses and that angelicin may provide a lead structure for the development of Antiviral drug against gammaherpesviruses.

Keywords

Angelicin; Antiviral activity; EBV; Furocoumarins; KSHV; MHV-68.

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