2. Academic Validation
  3. Violapyrones A-G, α-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces

Violapyrones A-G, α-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces

  • J Nat Prod. 2013 Nov 22;76(11):2126-30. doi: 10.1021/np4003417.
Jiaoyue Zhang 1,  Yi Jiang,  Yanru Cao,  Jiang Liu,  Dan Zheng,  Xiu Chen,  Li Han,  Chenglin Jiang,  Xueshi Huang
Affiliations

Affiliation

  • 1 Laboratory of Metabolic Disease Research and Drug Development, China Medical University , Shenyang 110001, People's Republic of China.
PMID: 24182355 DOI: 10.1021/np4003417
Abstract

Seven new 3,4,6-trisubstituted α-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate Antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 μg/mL.

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