2. Academic Validation
  3. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Ganesha Rai 1,  Akane Kawamura 2,  Anthony Tumber 2,  Yu Liang 3,  Jodi L. Vogel 3,  Jesse H. Arbuckle 3,  Nathan R. Rose 4,  Thomas S. Dexheimer 1,  Timothy L. Foley 1,  Oliver N. King 4,  Amy Quinn 1,  Bryan T. Mott 1,  Christopher J. Schofield 4,  Udo Oppermann 2,  Ajit Jadhav 1,  Anton Simeonov 1,  Thomas M. Kristie 3,  David J. Maloney 1
Affiliations

Affiliations

  • 1 NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD, 20850
  • 2 Structural Genomics Consortium, University of Oxford, UK
  • 3 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892
  • 4 Department of Chemistry, University of Oxford, UK
PMID: 24260783
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