Kadcotriones A-C: tricyclic triterpenoids from Kadsura coccinea

J Nat Prod. 2013 Dec 27;76(12):2350-4. doi: 10.1021/np400546z.

Cheng-Qin Liang ¹, Yi-Ming Shi, Xing-Yao Li, Rong-Hua Luo, Yan Li, Yong-Tang Zheng, Hong-Bin Zhang, Wei-Lie Xiao, Han-Dong Sun

Affiliations

Affiliation

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.

PMID: 24299567 DOI: 10.1021/np400546z

Abstract

Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 exhibited anti-HIV-1 activities with EC50 values of 30.29 and 54.81 μM, respectively.

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