2. Academic Validation
  3. Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation

Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation

  • Eur J Med Chem. 2014 Mar 21:75:143-50. doi: 10.1016/j.ejmech.2013.12.053.
Malla Reddy Gannarapu 1,  Sathish Babu Vasamsetti 2,  Nagender Punna 1,  Naresh Kumar Royya 1,  Shanthan Rao Pamulaparthy 1,  Jagadeesh Babu Nanubolu 3,  Srigiridhar Kotamraju 4,  Narsaiah Banda 5
Affiliations

Affiliations

  • 1 Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
  • 2 Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
  • 3 Centre for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
  • 4 Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India. Electronic address: giridhar@iict.res.in.
  • 5 Fluoroorganic Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India. Electronic address: narsaiah@iict.res.in.
PMID: 24531227 DOI: 10.1016/j.ejmech.2013.12.053
Abstract

A series of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives 7a-h and 9a-h were synthesized starting from sodium salt of saccharin 1 in series of steps. Final compounds 7a-h and 9a-h were evaluated for the anti-inflammatory activity and their ability to inhibit monocyte-to-macrophage transformation. Compounds 7e, 9b, 9e and 9h showed impressive anti-inflammatory activities (TNF-α, IL-8 and MCP-1) at micro molar concentration which was found to be better than positive control i.e., piroxicam. Compound 9e marginally and compound 9h significantly inhibited PMA-induced MMP-9 gelatinase activity. Also compounds 9e and 9h greatly inhibited the PMA-induced monocyte-to-macrophage transformation, a pre-requisite step in the formation of atheroma.

Keywords

Anti-inflammatory activity; N-aryl acetamide; Oxime ether; PMA-phorbol 12-myristate 13-acetate.

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