Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents

Eur J Med Chem. 2014 Apr 9:76:291-300. doi: 10.1016/j.ejmech.2014.02.013.

Maria E S B Barros ¹, Juliano C R Freitas ¹, Juliana M Oliveira ¹, Carlos H B da Cruz ¹, Paulo B N da Silva ², Larissa C C de Araújo ², Gardenia C G Militão ², Teresinha G da Silva ³, Roberta A Oliveira ¹, Paulo H Menezes ⁴

Affiliations

1 Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
2 Universidade Federal de Pernambuco, Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil.
3 Universidade Federal de Pernambuco, Departamento de Antibióticos, Cidade Universitária, Recife, PE, Brazil.
4 Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil. Electronic address: paulo.menezes@pq.cnpq.br.

PMID: 24589485 DOI: 10.1016/j.ejmech.2014.02.013

Abstract

(-)-Massoialactone, an α,β-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.

Keywords

Anti-inflammatory activity; Antitumoral activity; Lactones; Massoialactone; Tellurides.

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