2. Academic Validation
  3. Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall

Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall

  • Fitoterapia. 2014 Jun:95:258-65. doi: 10.1016/j.fitote.2014.03.014.
Mumtaz Ali 1,  Abdul Latif 2,  Khair Zaman 3,  Mohammad Arfan 4,  Derek Maitland 5,  Habib Ahmad 6,  Manzoor Ahmad 7
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: mumtazphd@gmail.com.
  • 2 Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan. Electronic address: dralatif@uom.edu.pk.
  • 3 Department of Chemistry, Abdul Wali Khan University, Mardan, Pakistan.
  • 4 Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
  • 5 Chemical and Forensic Sciences, University of Bradford, BD7 1DP, UK.
  • 6 Department of Genetics, Hazara University, Mansehra, Pakistan.
  • 7 Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan.
PMID: 24685505 DOI: 10.1016/j.fitote.2014.03.014
Abstract

Three new Xanthones, hypericorin C (1), hypericorin D (2) and 3,4-dihydroxy-5-methoxyxanthone (3), along with eight known compounds; 2,3-dimethoxyxanthone (4), 3,4-dihydroxy-2-methoxyxanthone (5), 3,5-dihydroxy-1-methoxyxanthone (6), 3-acetylbetulinic acid (7), 10H-1,3-dioxolo[4,5-b]xanthen-10-one (8), 3-hydroxy-2-methoxyxanthone (9), 3,4,5-trihydroxyxanthone (10) and betulinic acid (11) were isolated from the roots of Hypericum oblongifolium. The structures of the new compounds 1, 2 and 3 were deduced by spectroscopic techniques [ESI MS, (1)H NMR, (13)C NMR, and 2D NMR (HMQC, HMBC, COSY and NOESY)]. The entire series of compounds were evaluated for anti-ulcer activity.

Keywords

2D-NMR; Anti-ulcer; Hypericorin C; Hypericorin D; Hypericum oblongifolium Wall; Xanthones.

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