2. Academic Validation
  3. Diterpenoids from Croton laui and their cytotoxic and antimicrobial activities

Diterpenoids from Croton laui and their cytotoxic and antimicrobial activities

  • J Nat Prod. 2014 Apr 25;77(4):1013-20. doi: 10.1021/np500042c.
Cui-Ping Liu 1,  Jin-Biao Xu,  Jin-Xin Zhao,  Cheng-Hui Xu,  Lei Dong,  Jian Ding,  Jian-Min Yue
Affiliations

Affiliation

  • 1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
PMID: 24735527 DOI: 10.1021/np500042c
Abstract

Fourteen new Diterpenoids including clerodane (1-12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed by single-crystal X-ray crystallography. Crotonolide A (1) exhibited moderate cytotoxicity against two tumor cell lines, HL-60 (human premyelocytic leukemia, IC50 9.42 μM) and P-388 (murine leukemia, IC50 7.45 μM), and crotonolide G (10) displayed significant Antibacterial activity against a panel of Gram-positive bacteria.

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