2. Academic Validation
  3. Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity

  • Eur J Med Chem. 2014 Oct 6:85:245-54. doi: 10.1016/j.ejmech.2014.07.103.
Dmytro Havrylyuk 1,  Borys Zimenkovsky 1,  Olexandr Karpenko 2,  Philippe Grellier 3,  Roman Lesyk 4
Affiliations

Affiliations

  • 1 Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv 79010, Ukraine.
  • 2 Enamine Ltd., Alexandra Matrosova 23, Kyiv 01103, Ukraine.
  • 3 National Museum of Natural History, UMR 7245 CNRS-MNHN, Team BAMEE, CP 52, 57 Rue Cuvier, 75005 Paris, France.
  • 4 Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv 79010, Ukraine. Electronic address: dr_r_lesyk@org.lviv.net.
PMID: 25089808 DOI: 10.1016/j.ejmech.2014.07.103
Abstract

A series of novel 4-thiazolidinone-pyrazoline conjugates have been synthesized and tested for anti-Trypanosoma brucei activity. Screening data allowed us to identify five thiazolidinone-pyrazoline hybrids, which possess promising trypanocidal activity, with IC50 ≤ 1.2 μM. The highest active thiazolidinone-pyrazoline conjugates 3c and 6b (IC50 values of 0.6 μM and 0.7 μM, respectively) were 6-times more potent antitrypanosomal agents than nifurtimox. In addition, these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox. SAR study included substituent variations at the pyrazoline moiety, modifications of N3 position of the thiazolidinone portion, elongation of the linker between the heterocycles, as well as rhodanine-isorhodanine isomerism. It was also shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity.

Keywords

4-Thiazolidinones; Antitrypanosomal activity; Pyrazolines; Synthesis.

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