2. Academic Validation
  3. Five new anthraquinones from the seed of Cassia obtusifolia

Five new anthraquinones from the seed of Cassia obtusifolia

  • Arch Pharm Res. 2015 Jun;38(6):1054-8. doi: 10.1007/s12272-014-0462-x.
Yi-Long Xu 1,  Li-Ying Tang,  Xi-Dan Zhou,  Guo-Hong Zhou,  Zhu-Ju Wang
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Materia Madica, Chinese Academy of Chinese Medical Sciences, Beijing, 100700, People's Republic of China.
PMID: 25142941 DOI: 10.1007/s12272-014-0462-x
Abstract

A phytochemical investigation on the seeds of Cassia obtusifolia led to the isolation of five new Anthraquinones, including one aglycon and four glycosides. The structures were elucidated by analysis of extensive spectroscopic data and the results of acid hydrolysis. All these isolates were evaluated for their inhibitory effects against α-glucosidase, and 1 showed potent activity with IC50 value of 185 ± 15 µM.

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