2. Academic Validation
  3. DISP3 promotes proliferation and delays differentiation of neural progenitor cells

DISP3 promotes proliferation and delays differentiation of neural progenitor cells

  • FEBS Lett. 2014 Nov 3;588(21):4071-7. doi: 10.1016/j.febslet.2014.09.036.
Martina Zíková 1,  Jana Konířová 1,  Karolína Ditrychová 1,  Alicia Corlett 1,  Michal Kolář 1,  Petr Bartůněk 2
Affiliations

Affiliations

  • 1 Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic.
  • 2 Institute of Molecular Genetics AS CR v.v.i., Vídeňská 1083, 142 20 Prague 4, Czech Republic. Electronic address: bartunek@img.cas.cz.
PMID: 25281927 DOI: 10.1016/j.febslet.2014.09.036
Abstract

DISP3 (PTCHD2), a sterol-sensing domain-containing protein, is highly expressed in neural tissue but its role in neural differentiation is unknown. In the present study we used a multipotent cerebellar progenitor cell line, C17.2, to investigate the impact of DISP3 on the proliferation and differentiation of neural precursors. We found that ectopically expressed DISP3 promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. Finally, the differentiation profile of DISP3-expressing cells was altered, as evidenced by delayed expression of neural specific markers and a reduced capacity to undergo neural differentiation.

Keywords

Cancer; Differentiation; Lipids; Neural cells; Proliferation.

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