2. Academic Validation
  3. N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

  • J Med Chem. 2014 Dec 26;57(24):10455-63. doi: 10.1021/jm501501a.
Oscar M Bautista-Aguilera 1,  Abdelouahid Samadi,  Mourad Chioua,  Katarina Nikolic,  Slavica Filipic,  Danica Agbaba,  Elena Soriano,  Lucía de Andrés,  María Isabel Rodríguez-Franco,  Stefano Alcaro,  Rona R Ramsay,  Francesco Ortuso,  Matilde Yañez,  José Marco-Contelles
Affiliations

Affiliation

  • 1 Laboratorio de Química Médica, (IQOG, CSIC) , Juan de la Cierva 3, E-28006 Madrid, Spain.
PMID: 25418133 DOI: 10.1021/jm501501a
Abstract

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and Monoamine Oxidase dual inhibitor.

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