2. Academic Validation
  3. Lipoxygenase inhibitory activity of Cuspidaria pulchra and isolated compounds

Lipoxygenase inhibitory activity of Cuspidaria pulchra and isolated compounds

  • Nat Prod Res. 2015;29(11):1083-6. doi: 10.1080/14786419.2014.981182.
Tavane A Alvarenga 1,  Camila S Bertanha,  Pollyanna F de Oliveira,  Denise C Tavares,  Valéria M M Gimenez,  Márcio L A Silva,  Wilson R Cunha,  Ana H Januário,  Patrícia M Pauletti
Affiliations

Affiliation

  • 1 a Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca , Av. Dr. Armando Salles de Oliveira, 201, 14404-600 Franca , Brazil.
PMID: 25428032 DOI: 10.1080/14786419.2014.981182
Abstract

This work evaluated the in vitro inhibitory activity of the crude ethanolic extract from the aerial parts of Cuspidaria pulchra (Cham.) L.G. Lohmann against 15-lipoxygenase (15-LOX). The bioassay-guided fractionation of the n-butanol fraction, which displayed the highest activity, led to the isolation of three compounds: caffeoylcalleryanin (1), verbascoside (2) and 6-hydroxyluteolin-7-O-β-glucoside (3). Assessment of the ability of the isolated compounds to inhibit 15-LOX revealed that compounds 1, 2 and 3 exerted strong 15-LOX inhibitory activity; IC50 values were 1.59, 1.76 and 2.35 μM respectively. The XTT assay showed that none of the isolated compounds seemed to be significantly toxic.

Keywords

15-lipoxygenase inhibitory activity; Arrabidaea; cytotoxic activity.

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