2. Academic Validation
  3. MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1

  • Biochem Biophys Res Commun. 2014 Nov 7;454(1):109-14. doi: 10.1016/j.bbrc.2014.10.049.
Zhan-Guo Zhang 1,  Wei-Xun Chen 2,  Yan-Hui Wu 3,  Hui-Fang Liang 4,  Bi-Xiang Zhang 5
Affiliations

Affiliations

  • 1 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: zhang_zhanguo@hotmail.com.
  • 2 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: chenweixunclark@163.com.
  • 3 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: wuyanhui84@126.com.
  • 4 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: lianghuifang1997@126.com.
  • 5 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: bixiangzhang@163.com.
PMID: 25450365 DOI: 10.1016/j.bbrc.2014.10.049
Abstract

Accumulating evidence indicates that miRNAs play critical roles in tumorigenesis and Cancer progression. This study aims to investigate the role and the underlying mechanism of miR-132 in breast Cancer. Here, we report that miR-132 is significantly down-regulated in breast Cancer tissues and Cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1 transcript, thereby, suppressing multiple oncogenic traits such as Cancer cell proliferation, invasion, migration and metastasis in vivo and in vitro. Overexpression of HN1 restores miR-132-suppressed malignancy. Importantly, higher HN1 expression is significantly associated with worse overall survival of breast Cancer patients. Taken together, our data demonstrate a critical role of miR-132 in prohibiting cell proliferation, invasion, migration and metastasis in breast Cancer through direct suppression of HN1, supporting the potential utility of miR-132 as a novel therapeutic strategy against breast Cancer.

Keywords

Breast cancer; HN1; Tumor suppressor; miR-132.

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