2. Academic Validation
  3. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion

Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion

  • Molecules. 2014 Dec 4;19(12):20340-9. doi: 10.3390/molecules191220340.
Myoung-Jun Jang 1,  Ye Sol Kim 2,  Eun Young Bae 3,  Tae-Seok Oh 4,  Hwa-Jung Choi 5,  Jung-Hee Lee 6,  Hyun-Mee Oh 7,  Seung Woong Lee 8
Affiliations

Affiliations

  • 1 Enviromental Agriculture Research Division, Gyeonggido Agricultural Reaearch and Extension Services(GARES), Hwaseong, Gyeonggi-do 445-784, Korea. jplant119@gmail.com.
  • 2 Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea. yesolkim@kribb.re.kr.
  • 3 LINC project group, University Industry Cooperation, Daejeon University, Daejeon 300-716, Korea. eunjs75@dju.kr.
  • 4 Department of Plant Resources, Kongju National University, Yesan 340-702, Korea. ots1022@naver.com.
  • 5 Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea. rerived@kwu.ac.kr.
  • 6 Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea. jh4471@kwu.ac.kr.
  • 7 Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea. ohhm@kribb.re.kr.
  • 8 Department of Chemistry, Mokwon University, Daejeon 302-729, Korea. lswdoc@mokwon.ac.kr.
PMID: 25486247 DOI: 10.3390/molecules191220340
Abstract

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.

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