2. Academic Validation
  3. Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolata

Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolata

  • Bioorg Med Chem Lett. 2015 Apr 1;25(7):1483-9. doi: 10.1016/j.bmcl.2015.02.026.
Shuangshuang Zhao 1,  Junhong Ling 2,  Zhanlin Li 3,  Silong Wang 4,  Jiangchun Hu 5,  Nan Wang 6
Affiliations

Affiliations

  • 1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 2 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 3 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 4 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China; Huitong Experimental Station of Forest Ecology, Chinese Academy of Sciences, Huitong 418307, China.
  • 5 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.
  • 6 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address: wangn@iae.ac.cn.
PMID: 25736997 DOI: 10.1016/j.bmcl.2015.02.026
Abstract

Nine new diterpenes named lanceolatanol hydroperoxide (1), epilanceolatanol hydroperoxide (2), lanceolatanoic acid hydroperoxide (3), epilanceolatanoic acid hydroperoxide (4), lanceolatanol (5), lanceolatanoic acid (6), 11-acetoxylanceolatanoic acid (7), 11-acetoxylanceolatanoic acid methyl ester (8) and epoxyhinokiol (13) were characterized from the leaves of plantation-grown Cunninghamia lanceolata along with twelve known compounds. The compounds were evaluated for their growth inhibitory activities against the human prostate cell line (PC-3).

Keywords

Abietane; Cunninghamia lanceolata; Diterpenoid; Hydroperoxide; Labdane.

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