2. Academic Validation
  3. Effects of alkyl parabens on plant pathogenic fungi

Effects of alkyl parabens on plant pathogenic fungi

  • Bioorg Med Chem Lett. 2015 Apr 15;25(8):1774-1777. doi: 10.1016/j.bmcl.2015.02.049.
Shinsaku Ito 1,  Satoru Yazawa 1,  Yasutaka Nakagawa 1,  Yasuyuki Sasaki 1,  Shunsuke Yajima 2
Affiliations

Affiliations

  • 1 Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan.
  • 2 Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan. Electronic address: yshun@nodai.ac.jp.
PMID: 25791450 DOI: 10.1016/j.bmcl.2015.02.049
Abstract

Alkyl parabens are used as antimicrobial Preservatives in cosmetics, food, and pharmaceutical products. However, the mode of action of these chemicals has not been assessed thoroughly. In this study, we determined the effects of alkyl parabens on plant pathogenic fungi. All the fungi tested, were susceptible to parabens. The effect of linear alkyl parabens on plant pathogenic fungi was related to the length of the alkyl chain. In addition, the Antifungal activity was correlated with the paraben-induced inhibition of oxygen consumption. The Antifungal activity of linear alkyl parabens likely originates, at least in part, from their ability to inhibit the membrane respiratory chain, especially mitochondrial complex II. Additionally, we determined that some alkyl parabens inhibit Alternaria brassicicola Infection of cabbage.

Keywords

Black leaf spot disease; Drug design; Gallate; Mitochondrial complex II; Paraben; Structure–activity relationship study.

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