New organochalcogen multitarget drug: synthesis and antioxidant and antitumoral activities of chalcogenozidovudine derivatives

J Med Chem. 2015 Apr 23;58(8):3329-39. doi: 10.1021/jm5015296.

Diego de Souza ¹, Douglas O C Mariano ¹, Fernanda Nedel ², Eduarda Schultze ², Vinícius F Campos ², Fabiana Seixas ², Rafael S da Silva ¹, Taiana S Munchen ¹, Vinicius Ilha ¹, Luciano Dornelles ¹, Antonio L Braga ³, João B T Rocha ¹, Tiago Collares ², Oscar E D Rodrigues ¹

Affiliations

1 †LabSelen-NanoBio - Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, Brazil.
2 §Molecular and Cellular Oncology Group, Graduate Program in Biotechnology, Universidade Federal de Pelotas, 96010-610 Pelotas, Brazil.
3 ‡Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, Brazil.

PMID: 25811955 DOI: 10.1021/jm5015296

Abstract

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.

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