2. Academic Validation
  3. UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation

  • Mol Pharmacol. 2015 Jul;88(1):151-60. doi: 10.1124/mol.115.098756.
Eduardo R Lazarowski 1,  T Kendall Harden 2
Affiliations

Affiliations

  • 1 Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina.
  • 2 Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina tkh@med.unc.edu.
PMID: 25829059 DOI: 10.1124/mol.115.098756
Abstract

UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 Receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and Other cells.

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