Diterpenoids and Triterpenoids from the Resin of Bursera microphylla and Their Cytotoxic Activity

J Nat Prod. 2015 May 22;78(5):1184-8. doi: 10.1021/acs.jnatprod.5b00112.

Federica Messina ¹, Massimo Curini ¹, Chiara Di Sano ², Claudia Zadra ³, Giulia Gigliarelli ¹, Luisa Alondra Rascón-Valenzuela ⁴, Ramón Enrique Robles Zepeda ⁴, Maria Carla Marcotullio ¹

Affiliations

1 †Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy.
2 ‡Department of Oncohematology, University of Perugia, Santa Maria Hospital, Via Tristano di Joanuccio, 1-05100 Terni, Italy.
3 §Department of Pharmaceutical Sciences, University of Perugia, Borgo XX Giugno, 74-06121 Perugia, Italy.
4 ⊥Department of Chemical and Biological Science, University of Sonora, Hermosillo, Sonora, Mexico.

PMID: 25966052 DOI: 10.1021/acs.jnatprod.5b00112

Abstract

A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The antiproliferative activity of the major compounds was evaluated in different murine Cancer cell lines (M12.C3.F6 and RAW264.7) and human Cancer cells (A549, HeLa, and PC-3). The new compounds (1-3) did not show significant antiproliferative activity. The known compounds ariensin (4), burseran (5), and dihydroclusin diacetate (6) were effective against the RAW264.7 cell line, with IC50 values in the micromolar range.

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