Limonoids with Anti-HIV Activity from Cipadessa cinerascens

J Nat Prod. 2015 Jun 26;78(6):1243-52. doi: 10.1021/acs.jnatprod.5b00025.

Jin-Hai Yu ¹, Guo-Cai Wang ¹, Ying-Shan Han ², Yan Wu ¹, Mark A Wainberg ², Jian-Min Yue ¹

Affiliations

1 †State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
2 ‡McGill University AIDS Centre, The Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal, Quebec, Canada H3T 1E2.

PMID: 25970729 DOI: 10.1021/acs.jnatprod.5b00025

Abstract

Sixteen new limonoids, named ciparasins A-P (1-16), comprising three structural categories of trijugin-type (1-7), cipadesin-type (8-15), and prieurianin-type (16) compounds, as well as 15 known limonoid analogues (17-31), were isolated from Cipadessa cinerascens. Ciparasins E-G (5-7) were found to possess a rare γ-hydroxylbutenolide moiety at C-17. Ciparasins B (2) and P (16) showed significant anti-HIV activities, with EC50 values of 5.5 ± 0.6 (SI >7.2) and 6.1 ± 0.7 (SI >6.5) μM, respectively.

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