2. Academic Validation
  3. Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms

Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms

  • Acta Biochim Biophys Sin (Shanghai). 2015 Jul;47(7):477-87. doi: 10.1093/abbs/gmv041.
Guang-Zhe Ge 1,  Tian-Rui Xu 2,  Ceshi Chen 3
Affiliations

Affiliations

  • 1 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
  • 2 Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China chenc@mail.kiz.ac.cn xtrgfq@hotmail.com.
  • 3 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China chenc@mail.kiz.ac.cn xtrgfq@hotmail.com.
PMID: 26040315 DOI: 10.1093/abbs/gmv041
Abstract

Tobacco usage is a major risk factor in the development, progression, and outcomes for lung Cancer. Of the carcinogens associated with lung Cancer, tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is among the most potent ones. The oncogenic mechanisms of NNK are not entirely understood, hindering the development of effective strategies for preventing and treating smoking-associated lung cancers. Here, we introduce the NNK-induced lung Cancer animal models in different species and its potential mechanisms. Finally, we summarize several chemopreventive agents developed from these animal models.

Keywords

NNK; animal model; lung cancer; oncogenic mechanisms.

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