1. Academic Validation
  2. Coumarins as anticancer agents: a review on synthetic strategies, mechanism of action and SAR studies

Coumarins as anticancer agents: a review on synthetic strategies, mechanism of action and SAR studies

  • Eur J Med Chem. 2015 Aug 28:101:476-95. doi: 10.1016/j.ejmech.2015.07.010.
Anuradha Thakur 1 Ramit Singla 1 Vikas Jaitak 2
Affiliations

Affiliations

  • 1 Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151 001, India.
  • 2 Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda 151 001, India. Electronic address: vikasjaitak@gmail.com.
Abstract

Coumarins are fused benzene and pyrone ring systems which prompt biological investigation to assess their potential therapeutic significance. It possesses immeasurable Anticancer potential with minimum side effects depending on the substitutions on the basic nucleus. Coumarins have a tremendous ability to regulate diverse range of cellular pathways that can be explored for selective Anticancer activity. This is the first standalone review that emphasis on the assorted retrosynthetic approaches, important targets for molecularly targeted Cancer therapy and structure activity relationship studies that highlight the chemical groups responsible for evoking the Anticancer potential of coumarin derivatives reported from 2011 to 2014.

Keywords

Anticancer; Coumarins; IC(50); SAR; Synthesis; Targets.

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