2. Academic Validation
  3. Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens

Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens

  • J Nat Prod. 2015 Aug 28;78(8):2057-66. doi: 10.1021/acs.jnatprod.5b00380.
An Jin 1,  Wen-Ming Wu 1,  Heng-Yi Yu 2,  Ming Zhou 1,  Ye Liu 1,  Tian Tian 1,  Han-Li Ruan 1
Affiliations

Affiliations

  • 1 Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Hangkonglu 13, Wuhan 430000, People's Republic of China.
  • 2 Department of Pharmacy, Tongji Hospital Affiliated Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
PMID: 26200396 DOI: 10.1021/acs.jnatprod.5b00380
Abstract

Twenty-two new highly oxygenated bisabolane-type sesquiterpenoids, pararubin A-V (1-22), were isolated from the whole plant of Parasenecio rubescens. The structure determination of 1-22, including the assignment of their relative configurations, was accomplished by extensive 1D and 2D NMR spectroscopy. The absolute configuration of pararubin A (1) was established by single-crystal X-ray crystallographic analysis. The isolated compounds were evaluated for their cytotoxic effects against three Cancer cell lines (B16 mouse melanoma cells, HepG2 human hepatocellular carcinoma cells, and MCF7 human breast adenocarcinoma cells) and for their antimicrobial effects against Staphylococcus aureus, Escherichia coli, and Monilia albicans.

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