2. Academic Validation
  3. Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum

Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum

  • J Nat Prod. 2015 Aug 28;78(8):2074-86. doi: 10.1021/acs.jnatprod.5b00394.
Russell B Williams 1,  Vanessa L Norman 1,  Mark O'Neil-Johnson 1,  Scott Woodbury 2,  Gary R Eldridge 1,  Courtney M Starks 1
Affiliations

Affiliations

  • 1 Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, Missouri 63114, United States.
  • 2 Whitmire Wildflower Garden, Shaw Nature Reserve, Missouri Botanical Garden, P.O. Box 38, Gray Summit, Missouri 63039, United States.
PMID: 26287548 DOI: 10.1021/acs.jnatprod.5b00394
Abstract

The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The Plants of the tallgrass prairie historically have been subjected to a number of biological and environmental stresses. Among the adaptations developed by S. laciniatum is a large deep taproot. An investigation of the secondary metabolites found in the root of a S. laciniatum specimen has led to the identification of 15 new Terpenoids (3-8, 10-17, and 22), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line.

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