2. Academic Validation
  3. Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus

Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus

  • Med Sci Monit. 2015 Sep 7;21:2653-8. doi: 10.12659/MSM.893607.
Hui Peng 1,  Jiamei Li 1,  Xiaoyun Chen 2,  Xiao Zhou 3,  Weiwei Zhu 4,  Feng Li 4
Affiliations

Affiliations

  • 1 Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
  • 2 Department of Pediatrics, Taian Central Hospital, Taian, Shandong, China (mainland).
  • 3 Department of pediatrics, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China (mainland).
  • 4 Department of Pediatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
PMID: 26344020 DOI: 10.12659/MSM.893607
Abstract

Background: Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in the PTPN2 gene and T1DM in Chinese Han children.

Material and methods: This case-control study included 141 Chinese Han children with T1DM and 282 healthy controls. Genetic variants of rs478582 and rs2542151 in PTPN2 gene were performed by PCR amplification followed by restriction fragment length polymorphism method.

Results: No difference was observed in association of rs478582 in The PTPN2 gene and T1DM. The distribution of allele frequency of rs2542151 differed significantly between T1DM patients and healthy controls (OR, 0.6; 95%CI: 0.44 to 0.95; and P=0.024). Dominant model of rs254215 also was associated with T1DM (OR, 0.6; 95%CI: 0.40 to 0.96; and P=0.032). Younger age at onset in G carriers appeared to increase the risk for T1DM (P=0.030).

Conclusions: The findings suggested that rs2542151 SNP in The PTPN2 gene was associated with T1DM in Chinese Han children. Further studies with larger sample sizes involving gene-gene interactions are urgently needed.

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