2. Academic Validation
  3. Wnt3a: functions and implications in cancer

Wnt3a: functions and implications in cancer

  • Chin J Cancer. 2015 Sep 14;34(12):554-62. doi: 10.1186/s40880-015-0052-4.
Sha He 1 2,  Yi Lu 3 4,  Xia Liu 5 6,  Xin Huang 7 8,  Evan T Keller 9,  Chao-Nan Qian 10,  Jian Zhang 11 12 13
Affiliations

Affiliations

  • 1 Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.
  • 2 Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. 514239052@qq.com.
  • 3 Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. luyi5555@hotmail.com.
  • 4 Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. luyi5555@hotmail.com.
  • 5 Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. realliuxia@sina.com.
  • 6 Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. realliuxia@sina.com.
  • 7 Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. xin.huang2005@gmail.com.
  • 8 Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. xin.huang2005@gmail.com.
  • 9 Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. etkeller@umich.edu.
  • 10 Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, 51006, P.R. China. qianchn@sysucc.org.cn.
  • 11 Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning, Guangxi, 530021, P.R. China. jianzhang008@hotmail.com.
  • 12 Center for Translational Medicine, Guangxi Medical University, Nanning, Guangxi, 530021, P.R. China. jianzhang008@hotmail.com.
  • 13 Department of Urology and Pathology, School of Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. jianzhang008@hotmail.com.
PMID: 26369691 DOI: 10.1186/s40880-015-0052-4
Abstract

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on Cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in Cancer.

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