Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents

J Med Chem. 2015 Nov 12;58(21):8734-8. doi: 10.1021/acs.jmedchem.5b00804.

Pramod K Sahu ¹, Tamima Umme ², Jinha Yu ¹, Akshata Nayak ¹ ², Gyudong Kim ¹, Minsoo Noh ¹, Jae-Young Lee ¹, Dae-Duk Kim ¹, Lak Shin Jeong ¹

Affiliations

1 Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University , Seoul 151-742, Korea.
2 College of Pharmacy, Ewha Womans University , Seoul 120-750, Korea.

PMID: 26460883 DOI: 10.1021/acs.jmedchem.5b00804

Abstract

On the basis of the potent Antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new Antiviral agents.

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