2. Academic Validation
  3. Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum

Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum

  • J Nat Prod. 2015 Nov 25;78(11):2837-40. doi: 10.1021/acs.jnatprod.5b00627.
Haoxin Li 1,  Stéphanie Jean 2 3,  Duncan Webster 4,  Gilles A Robichaud 2 3,  Larry A Calhoun 5,  John A Johnson 1,  Christopher A Gray 1 5
Affiliations

Affiliations

  • 1 Department of Biology, University of New Brunswick , Saint John, New Brunswick, Canada E2L 4L5.
  • 2 Department of Chemistry and Biochemistry, Université de Moncton , Moncton, New Brunswick, Canada E1A 3E9.
  • 3 Atlantic Cancer Research Institute , Moncton, New Brunswick, Canada E1C 8X3.
  • 4 Department of Medicine, Division of Infectious Diseases, Saint John Regional Hospital , Saint John, New Brunswick, Canada E2L 4L2.
  • 5 Department of Chemistry, University of New Brunswick , 30 Dineen Drive, Fredericton, New Brunswick, Canada E3B 5A3.
PMID: 26473275 DOI: 10.1021/acs.jnatprod.5b00627
Abstract

Two new dibenz[b,f]oxepins, empetroxepins A and B (1 and 2), and seven known compounds (3-9) were isolated from an extract of the Canadian medicinal plant Empetrum nigrum that significantly inhibited the growth of Mycobacterium tuberculosis H37Ra. The structures of 1 and 2 were established through analysis of NMR and MS data. The antimycobacterial activity of the plant extract was attributed primarily to the presence of two chalcone derivatives (6 and 7) that exhibited selective antimycobacterial activity (IC50 values of 23.8 and 32.8 μM, respectively) in comparison to mammalian (HEK 293) cells (IC50 values of 109 and 249 μM, respectively).

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