2. Academic Validation
  3. Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

  • J Nat Prod. 2015 Nov 25;78(11):2841-5. doi: 10.1021/acs.jnatprod.5b00742.
Xueqian He 1,  Zhenzhen Zhang 1,  Yinghan Chen 1,  Qian Che 1,  Tianjiao Zhu 1,  Qianqun Gu 1,  Dehai Li 1
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
PMID: 26561719 DOI: 10.1021/acs.jnatprod.5b00742
Abstract

A new, highly modified fatty acid amide, varitatin A (1), was isolated from the fungus Penicillium variabile HXQ-H-1 cultivated with the DNA Methyltransferase Inhibitor 5-azacytidine. The structure including the absolute configuration of 1 was established by analysis of NMR and MS data, together with chemical degradation and Mosher's method based on MPA esters. Compound 1 showed cytotoxicity against HCT-116 cells with an IC50 value of 2.8 μM and also inhibited the effects of Protein Tyrosine Kinases.

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