2. Academic Validation
  3. Two new peroxy fatty acids with antibacterial activity from Ophioglossum thermale Kom

Two new peroxy fatty acids with antibacterial activity from Ophioglossum thermale Kom

  • Fitoterapia. 2016 Mar;109:212-6. doi: 10.1016/j.fitote.2015.12.019.
Jian-Wei Dong 1,  Le Cai 1,  Xue-Jiao Li 1,  Li Peng 1,  Yun Xing 1,  Rui-Feng Mei 1,  Jia-Peng Wang 1,  Zhong-Tao Ding 2
Affiliations

Affiliations

  • 1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
  • 2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: ztding@ynu.edu.cn.
PMID: 26742995 DOI: 10.1016/j.fitote.2015.12.019
Abstract

Two new peroxy fatty acids, thermalic acids A (1) and B (2), together with eight known compounds, (3β)-methyl-3-hydroxy-urs-11-en-28 oate (3), luteolin (4), quercetin (5), 3-methoxyquercetin (6), ophioglonol (7), ophioglonol 4'-O-α-D-glucopyranoside (8), pedunculosumoside B (9), syringol (10), were isolated from the herba of Ophioglossum thermale Kom. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. Both two acids exhibited potential Antibacterial activities against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. This is the first report of peroxy fatty acids isolated from herbaceous Plants of Ophioglossaceae.

Keywords

Antibacterial activity; Ophioglossum thermale Kom.; Peroxy fatty acid; Thermalic acid A; Thermalic acid B.

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