2. Academic Validation
  3. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

  • J Nat Prod. 2016 Mar 25;79(3):578-83. doi: 10.1021/acs.jnatprod.5b01012.
Cheng Jiang 1,  Pan Luo 1,  Yu Zhao 2,  Jialing Hong 1,  Susan L Morris-Natschke 2,  Jun Xu 1,  Chin-Ho Chen 3,  Kuo-Hsiung Lee 2 4,  Qiong Gu 1 2
Affiliations

Affiliations

  • 1 Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, People's Republic of China.
  • 2 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
  • 3 Duke University Medical Center , Box 2926, SORF, Durham, North Carolina 27710, United States.
  • 4 Chinese Medicine Research and Development Center, China Medical University and Hospital , Taichung 401, Taiwan.
PMID: 26756779 DOI: 10.1021/acs.jnatprod.5b01012
Abstract

Seven new carolignans, including two pairs of enantiomers (±)-erythro-7'-methylcarolignan E (1a/1b) and (±)-threo-7'-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (-)-erythro-carolignan Z (5), together with four known Lignans (3b, 4b, 6, and 7) and six Polyphenols (8-13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC50 values of 6.3 and 5.3 μM.

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