2. Academic Validation
  3. Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces

Bafilomycins and Odoriferous Sesquiterpenoids from Streptomyces albolongus Isolated from Elephas maximus Feces

  • J Nat Prod. 2016 Apr 22;79(4):799-805. doi: 10.1021/acs.jnatprod.5b00827.
Nan Ding 1 2,  Yi Jiang 3,  Li Han 1,  Xiu Chen 1,  Jian Ma 1,  Xiaodan Qu 1,  Yu Mu 1,  Jiang Liu 1,  Liya Li 1,  Chenglin Jiang 3,  Xueshi Huang 1
Affiliations

Affiliations

  • 1 Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University , Shenyang 110819, People's Republic of China.
  • 2 Laboratory of Metabolic Disease Research and Drug Development, China Medical University , Shenyang 110001, People's Republic of China.
  • 3 Yunnan Institute of Microbiology, Yunnan University , Kunming 650091, People's Republic of China.
PMID: 26933756 DOI: 10.1021/acs.jnatprod.5b00827
Abstract

From a fermentation broth of Streptomyces albolongus obtained from Elephas maximus feces, nine bafilomycins (1-9) and seven odoriferous sesquiterpenoids (10-16) were isolated. The structures of the new compounds, including three bafilomycins, 19-methoxybafilomycin C1 amide (1), 21-deoxybafilomycin A1 (2), and 21-deoxybafilomycin A2 (3), and two sesquiterpenoid degradation products, (1β,4β,4aβ,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (10) and (1β,4β,4aβ,7α,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a,7(2H)-triol (11), were elucidated by comprehensive spectroscopic data analysis. The cytotoxicity activity against four human Cancer cell lines and antimicrobial activities against a panel of bacteria and fungi of all compounds isolated were evaluated. Compounds 1, 7, and 8 were cytotoxic, with IC50 values ranging from 0.54 to 5.02 μM. Compounds 2, 7, 8, and 10 showed strong Antifungal activity against Candida parapsilosis, with MIC values of 3.13, 1.56, 1.56, and 3.13 μg/mL respectively.

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