2. Academic Validation
  3. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level

Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level

  • Fitoterapia. 2016 Jun:111:1-6. doi: 10.1016/j.fitote.2016.03.018.
Jianwei Xu 1,  Wei Zhao 1,  Lanying Pan 1,  Ailian Zhang 1,  Qingmao Chen 2,  Kai Xu 2,  Haiyin Lu 1,  Yuan Chen 3
Affiliations

Affiliations

  • 1 Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
  • 2 Safety Pharmacology Division, Olivepharmasolutions Ltd, 333 Changhong Road, Wukang 313200, PR China.
  • 3 Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China. Electronic address: ychen@zafu.edu.cn.
PMID: 27033404 DOI: 10.1016/j.fitote.2016.03.018
Abstract

Fritillaria is one of the most important herbs in Chinese traditional medicine and represents an annual ￥700 million industry. It is often used as an anti-inflammatory, pain relieving and antitussive medicine. However, the mechanisms of these effects are still unclear. Peimine is one of active ingredients of Fritillaria. Using the patch-clamp technique, we profiled the action of Peimine against selected ion channels stably expressed in HEK 293 cell lines. Our data indicated that Peimine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel. Thus, the study suggested potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb.

Keywords

Fritillaria; Inflammation; Kv1.3; Nav1.7; Pain; Peimine.

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