2. Academic Validation
  3. Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions

Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions

  • Bioorg Med Chem. 2016 Jul 15;24(14):3108-15. doi: 10.1016/j.bmc.2016.05.030.
María Sánchez-Peris 1,  Eva Falomir 1,  Juan Murga 2,  Miguel Carda 1,  J Alberto Marco 3
Affiliations

Affiliations

  • 1 Depart. de Q. Inorgánica y Orgánica, Univ. Jaume I, E-12071 Castellón, Spain.
  • 2 Depart. de Q. Inorgánica y Orgánica, Univ. Jaume I, E-12071 Castellón, Spain. Electronic address: jmurga@uji.es.
  • 3 Depart. de Q. Orgánica, Univ. de Valencia, E-46100 Burjassot, Valencia, Spain.
PMID: 27259399 DOI: 10.1016/j.bmc.2016.05.030
Abstract

A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the activation of Telomerase, has also been determined.

Keywords

Antiangiogenesis; Biphenyl derivatives; Telomerase; VEGF; hTERT.

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