2. Academic Validation
  3. Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

  • J Nat Prod. 2016 Jun 24;79(6):1548-53. doi: 10.1021/acs.jnatprod.5b01106.
Qinghao Jin 1,  Jin Woo Lee 1,  Hari Jang 1,  Ji Eun Choi 1,  Dongho Lee 2,  Jin Tae Hong 1,  Youngsoo Kim 1,  Mi Kyeong Lee 1,  Bang Yeon Hwang 1
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
  • 2 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University , Seoul 02841, Korea.
PMID: 27276091 DOI: 10.1021/acs.jnatprod.5b01106
Abstract

Eight new Sesquiterpenes (1-8), along with seven known Sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.

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