2. Academic Validation
  3. Interaction of the novel agent amphethinile with tubulin

Interaction of the novel agent amphethinile with tubulin

  • Br J Cancer. 1989 Jun;59(6):865-8. doi: 10.1038/bjc.1989.183.
A T McGown 1,  B W Fox
Affiliations

Affiliation

  • 1 Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
PMID: 2736224 DOI: 10.1038/bjc.1989.183
Abstract

The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but not vinblastine from tubulin and causes a stimulation in GTPase activity in vitro. The affinity constant for the association of this drug with tubulin has been determined (Ka = 1.3 x 10(6) M-1). It is concluded that amphethinile belongs to the class of agents which share a common binding site with colchicine on the tubulin molecule.

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