2. Academic Validation
  3. Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride

Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride

  • J Nat Prod. 2016 Oct 28;79(10):2552-2558. doi: 10.1021/acs.jnatprod.6b00453.
Peng Sun 1,  Qing Yu 1,  Jiao Li 1,  Raffaele Riccio 2,  Gianluigi Lauro 2,  Giuseppe Bifulco 2,  Tibor Kurtán 3,  Attila Mándi 3,  Hua Tang 1,  Tie-Jun Li 1,  Chun-Lin Zhuang 1,  William H Gerwick 4,  Wen Zhang 1
Affiliations

Affiliations

  • 1 Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University , 325 Guo-He Road, Shanghai 200433, People's Republic of China.
  • 2 Dipartimento di Farmacia, Università di Salerno , Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy.
  • 3 Department of Organic Chemistry, University of Debrecen , POB 20, H-4010 Debrecen, Hungary.
  • 4 Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.
PMID: 27704808 DOI: 10.1021/acs.jnatprod.6b00453
Abstract

Two new biscembranoid-like compounds, bissubvilides A (1) and B (2), were isolated together with sarsolilide B (3), the proposed biogenetic precursor to 1, from the soft coral Sarcophyton subviride. The structures and absolute configurations were solved by spectroscopic analysis and TDDFT/ECD and DFT/NMR calculations. The bissubvilides represent a novel biscembranoid-like skeleton presumed to derive from a cembrane-type diene and a capnosane-type dienophile via a Diels-Alder reaction. These two molecules exerted no cytotoxicity against MG-63 or A549 tumor cells or HuH7 tumor stem cells.

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