Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5995-5998. doi: 10.1016/j.bmcl.2016.10.017.

Qinghao Jin ¹, Jin Woo Lee ², Hari Jang ², Ji Eun Choi ², Hyung Sik Kim ², Dongho Lee ³, Jin Tae Hong ², Mi Kyeong Lee ², Bang Yeon Hwang ⁴

Affiliations

1 College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea; Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.
2 College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea.
3 College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
4 College of Pharmacy, Chungbuk National University, Cheongju 28644, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.

PMID: 27865705 DOI: 10.1016/j.bmcl.2016.10.017

Abstract

Phytochemical investigation of the roots of Echinops latifolius led to the isolation of a new carbon skeleton dimeric sesquiterpene (1) and a new thiophene (2), along with six known compounds (3-8). Their structures and relative stereochemistry were elucidated by spectroscopic and spectrometric methods (¹H and ¹³C NMR, COSY, HSQC, HMBC, ROESY, and MS). All isolates were evaluated for their inhibition of LPS-induced NO production in RAW 264.7 cells. Compounds 4 and 5 exhibited the most potent inhibitory effects on NO production.

Keywords

Anti-inflammatory; Asteraceae; Dimeric sesquiterpene; Echinops latifolius; Thiophene.

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