Oropouche Virus: Clinical, Epidemiological, and Molecular Aspects of a Neglected Orthobunyavirus

Am J Trop Med Hyg. 2017 May;96(5):1019-1030. doi: 10.4269/ajtmh.16-0672.

Jorge Fernando Travassos da Rosa ¹, William Marciel de Souza ² ³, Francisco de Paula Pinheiro ¹, Mário Luiz Figueiredo ⁴, Jedson Ferreira Cardoso ¹, Gustavo Olszanski Acrani ⁵, Márcio Roberto Teixeira Nunes ¹ ⁶

Affiliations

1 Evandro Chagas Institute, Ministry of Health, Pará, Brazil.
2 MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland.
3 Virology Research Center, School of Medicine of Ribeirao Preto of University of São Paulo, São Paulo, Brazil.
4 Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
5 Universidade Federal da Fronteira Sul, Passo Fundo, Rio Grande do Sul, Brazil.
6 Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas.

PMID: 28167595 DOI: 10.4269/ajtmh.16-0672

Abstract

AbstractOropouche virus (OROV) is an important cause of arboviral illness in Latin American countries, more specifically in the Amazon region of Brazil, Venezuela and Peru, as well as in Other countries such as Panama. In the past decades, the clinical, epidemiological, pathological, and molecular aspects of OROV have been published and provide the basis for a better understanding of this important human pathogen. Here, we describe the milestones in a comprehensive review of OROV epidemiology, pathogenesis, and Molecular Biology, including a description of the first isolation of the virus, the outbreaks during the past six decades, clinical aspects of OROV Infection, diagnostic methods, genome and genetic traits, evolution, and viral dispersal.

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