Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1815-1819. doi: 10.1016/j.bmcl.2017.02.051.

Jianbin Wang ¹, Kehui Xie ¹, Hongquan Duan ², Yi Wang ¹, He Ma ³, Hongzheng Fu ⁴

Affiliations

1 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100191, People's Republic of China.
2 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy and Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, People's Republic of China.
3 Shandong Academy of Pharmaceutical Sciences, Jinan 250101, People's Republic of China.
4 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100191, People's Republic of China. Electronic address: drhzfu@sina.com.

PMID: 28302401 DOI: 10.1016/j.bmcl.2017.02.051

Abstract

Five new diterpenoid glycosides, siegesides A-E (1-5), along with the known compound darutoside (6) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens. The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds 1 and 2 are epimers of 6. All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast Cancer cells induced by the chemokine epithelial growth factor, and compound 2 showed superior inhibitory activities in comparison with the positive control drug with IC₅₀ value of 0.27μM.

Keywords

Chemokine epithelial growth factor; Diterpenoid glycosides; MB-MDA-231 breast cancer cells; Siegesbeckia pubescens.

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